Table 1.
Summary of study characteristics
| Study characteristic | Subgroups | Number of studies |
|---|---|---|
| Species | Guinea pig | 16 |
| Dog | 14 | |
| Rabbit | 12 | |
| Horse | 5 | |
| Cat | 1 | |
| Sheep | 1 | |
| OA model | Spontaneous | 19 |
| ACLT | 16 | |
| Groove model | 4 | |
| Meniscectomy | 4 | |
| Overloading | 3 | |
| Subchondral fracture | 1 | |
| Medial Release | 1 | |
| Osteochondral fragment | 1 | |
| Relative time points | Single | 19 |
| Multiple | 30 | |
| Skeletal maturity | Skeletally mature | 40 |
| Skeletally mature by end of study | 6 | |
| Not skeletally mature | 2 | |
| Unknown | 1 | |
| Cartilage degradation a | Mankin or modified Mankin | 24 |
| MRI | 11 | |
| Histologic characterization | 6 | |
| Histologic scoring | 3 | |
| OARSI | 6 | |
| Macroscopic scoring | 1 | |
| Bone structural parameters a | BMD | 18 |
| BV/BT | 22 | |
| Subchondral plate thickness | 27 | |
| Defect identification | 18 | |
| Stiffness | 6 |
Abbreviations: ACLT, anterior cruciate ligament transection; BMD, bone mineral density; BV/BT, bone volume fraction; MRI, magnetic resonance imaging; OA, osteoarthritis; OARSI, Osteoarthritis Research Society International.
a
Datasets may be counted in more than one subgrouping.