Table 1.

Summary of pharmacokinetic parameters.¹¹.

Absorption	Distribution	Metabolism	Elimination
Bioavailability: ~48% Tmax: ~20–40 min	Volume: ~709 l (based on intravenous administration) Protein binding: ~43–45%	Main initial metabolite, nor-esketamine (less active than parent drug) Cytochrome P450 iso-enzyme mediated-metabolism: 2D6 and 3A4, with some input from 2C9 and 2C19	Mean terminal half-life: ~7–12 h Urinary: metabolites, 78% Faeces: metabolites, <2%

T_max, time to maximum plasma concentration.