FIGURE 1.

Comparative components of the immune system and the extracellular matrix (ECM) between some vertebrates and invertebrates. The immune systems of invertebrates and vertebrates have similarities between innate and humoral responses. The innate immune response involves mainly phagocytic cells and the humoral response of secreted molecules. One of the main ECM proteins in all these organisms is collagen, which is a key molecule that must be successfully remodeled to establish scar‐free wound healing