Table 2.

Important publications concerning mechanistic aspects of the Huisgen reaction.

Year	Research Subject	Main author	Location	Ref.
1932	Stereospecific cycloadditions of diazomethane	K. von Auwers	Marburg	18
1934	Formula of diazomethane with correct Lewis structure	H. Boersch	Vienna	111
1953	Mechanism of ozonolyses of alkenes	R. Criegee	Karlsruhe	17
1954	Cycloadditions of diazomethane and phenyl azide to strained cycloalkenes	K. Ziegler	Mülheim/Ruhr	112
1957–1959	Mechanism of diazoalkane and aryl azide cycloadditions to norbornene derivatives	R. Huisgen	Munich	24
1960	General concept of 1,3‐dipolar cycloadditions	R. Huisgen	Munich	1
1961	Reaction of cyclooctyne with phenyl azide	G. Wittig	Heidelberg	104b
1963	Review: “Kinetics and Mechanism of 1,3‐Dipolar Cycloadditions”	R. Huisgen	Munich	39
1964	First calculations of activation enthalpies of alkene–diazoalkane cycloadditions	O. E. Polansky, P. Schuster	Vienna	52
1965	First publication concerning the conservation of orbital symmetry	R. B. Woodward, R. Hoffmann	Cambridge/USA	40
1967	Stereospecific ring‐opening of aziridines to give azomethine ylides and their cycloadditions	R. Huisgen	Munich	42
1968	Proposal of the diradical mechanism for 1,3‐dipolar cycloadditions and Diels–Alder reactions	R. A. Firestone	Rahway	43
1969	Woodward–Hoffmann Rules	R. B. Woodward, R. Hoffmann	Cambridge/USA, Ithaca	41
1971	Application of the frontier orbital model for the classification of reactivities in 1,3‐dipolar cycloadditions and Diels–Alder reactions	R. Sustmann	Münster	53
1972	Interpretation of the regioselectivity in 1,3‐dipolar cycloadditions with the frontier orbital model	J. Bastide K. N. Houk	Perpignan Baton Rouge	54 55
1975	Ab initio calculations of the reaction mechanism of the 1,3‐dipolar cycloaddition	D. Poppinger	Canberra	57
1978	Record stereospecificity of diazomethane cycloadditions	R. Huisgen	Munich	46
1986	First two‐step 1,3‐dipolar cycloadditions of thiocarbonyl ylides via zwitterions	R. Huisgen	Munich	50
2003	Concluding review: “1,3‐Dipolar Cycloadditions: Concertedness, Yes or No?”	R. Huisgen	Munich	113
2007	Distortion/interaction model for interpretation of 1,3‐dipolar cycloadditions	K. N. Houk	Los Angeles	66
2012	Olefin–carbonyl metathesis with the help of in situ generated azomethine imines	T. H. Lambert	New York	114
2018	Analysis of the concerted reaction mechanism of diazoalkane–alkene cycloadditions employing nucleophilicity–electrophilicity parameters	H. Mayr, A. R. Ofial, H. Zipse	Munich	48
2018	Last publication of R. Huisgen concerning 1,3‐dipolar cycloadditions: regioselectivity of heteroatom‐substituted alkynes with diazoalkanes	M. Breugst, R. Huisgen, H.‐U. Reissig	Cologne, Munich, Berlin	69