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. 2020 Jul 24;40(7):BSR20200825. doi: 10.1042/BSR20200825

Figure 1. CiRS-7 was up-regulated in OC tissues and an independent prognostic factor for TNM stages, lymph node metastasis status and overall survival in OC patients.

Figure 1

(A) relative ciRS-7 expression was statistically significantly higher in OC tissues (n=40) than in paired normal adjacent tissues (n=40) from 40 OC patients detected by qRT-PCR. (B) Relative ciRS-7 expression in OC tissues from stage III-IV patients (n=21) was statistically significantly higher than that in the OC tissues from stage I-II patients (n=19) detected by qRT-PCR. (C) Relative ciRS-7 expression level was statistically significantly higher in OC tissues of the positive lymph node metastasis group (n=17) than that in the negative lymph node metastasis group (n=23). (D) Overall survival rates were statistically significantly decreased in OC patients with high ciRS-7 expression. (E) Relative ciRS-7 expression was statistically significantly higher in the OC cells (SKOV3, A2780, OV2008, IGROV1, ES-2) than in the normal human cervical epithelial HOSE cells. Relative ciRS-7 expression was calculated by 2−ΔΔCt method using GAPDH as the internal control. All the experiments were repeated for three times; **P<0.01