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. 2020 Jul 24;40(7):BSR20200825. doi: 10.1042/BSR20200825

Figure 2. CiRS-7 silence inhibited proliferation, migration and invasion of OC cells in vitro as well as tumor growth in vivo.

Figure 2

(A) qRT-PCR analysis confirmed that the relative ciRS-7 expression, calculated by 2−ΔΔCt method using GAPDH as the internal control, was successfully silenced by si-ciRS-7 in the SKOV3 and the A2780 cells, the following phenotypes were then evaluated in the SKOV3 and A2780 cells transfected with the si-NC or si-ciRS-7: cell viability detected by CCK-8 assay in vitro (B) colony number detected by colony formation assay in vitro (C) tumor volume (D) and tumor weight (E) in the si-NC group (n=6) and the si-ciRS-7 group (n=6) detected in vivo using the xenograft mouse model; cell migration (F) and cell invasion (G) detected by transwell assay. All the experiments were repeated for three times; *P<0.01; **P<0.01.