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. 2020 Jul 24;40(7):BSR20200825. doi: 10.1042/BSR20200825

Figure 5. Ablation of miR-641 rescued the decreased malignant phenotype induced by ciRS-7 silence in OC cells.

Figure 5

(A) Cell viability in SKOV3 and A2780 cells after ciRS-7 knockdown with or without inh-miR-641 detected by CCK-8 assay. (B) Colony formation assay in SKOV3 and A2780 cells after ciRS-7 knockdown with or without inh-miR-641. (C) Cell migration ability in SKOV3 and A2780 cells after ciRS-7 knockdown with or without inh-miR-641 detected by the transwell assay without matrigel. (D) Cell invasion ability in SKOV3 and A2780 cells after ciRS-7 knockdown with or without inh-miR-641 detected by the transwell assay with matrigel; tumor volume (E) and tumor weight (F) in the si-NC group (n=6), and the si-ciRS-7 without inh-miR-641(si-ciRS-7) group (n=6) and the si-ciRS-7 with inh-miR-641 group (si-ciRS-7+inh-miR-641) group (n=6) detected in vivo using the xenograft mouse model. All the experiments were repeated for three times; *P<0.01; **P<0.01; ##P<0.01.