Table 5.
Correlations between expression levels of Notch, Numb, Itch, and Siah-1 and clinicopathological parameters in colorectal carcinoma
|
Levels |
n |
Notch |
Numb |
Itch |
Siah-1 |
|||||||
| Parameters |
(-) |
(↓) |
(↑) |
(↓) |
(↑) |
(-) |
(↓) |
(↑) |
(-) |
(↓) |
(↑) |
|
| 12 | 16 | 22 | 26 | 24 | 16 | 19 | 15 | 10 | 27 | 13 | ||
| Age | ||||||||||||
| 64 ± 12.353 ≥ | 22 | 7 (31.8) | 4 (18.2) | 11 (50) | 12 (54.5) | 10 (45.5) | 7 (31.8) | 6 (27.3) | 9 (40.9) | 4 (18.2) | 13 (59.1) | 5 (22.7) |
| 64 ± 12.353 < | 28 | 5 (17.9) | 12 ( 42 .9) | 11 (39.3) | 14 (50) | 14 (50) | 5 (17.9) | 12 (42.9) | 11(39.3) | 6 (21.4) | 14 (50) | 8 (28.6) |
| Gender | ||||||||||||
| Female | 17 | 3 (17.6) | 5 ( 29.5) | 9 (52.9) | 17 (51.5) | 16 (48.5) | 6 (35.3) | 7 (41.2) | 4 (23.4) | 3 (17.6) | 10 (58.8) | 4 (23.5) |
| Male | 33 | 9 (27.3) | 11 (33.3) | 13 (39.4) | 9 (52.9) | 8 (47.1) | 6 (18.2) | 11 (33.3) | 16 (48.5) | 7 (21.2) | 17 (51.5 | 9 (27.3) |
| Localisation | ||||||||||||
| Caecum | 8 | 1 (12.5) | 3 (37.5) | 4 (50) | 4 (50) | 4(50) | 0 | 3 (37.5) | 5 (62.5) | 2 (25) | 4 (50) | 2 (25) |
| Colon | 16 | 3 (18.8) | 3 (18.8) | 10 (62.5) | 9 (56.2) | 7 (43.8) | 5 (31.2) | 5 (31.2) | 6 (37.5) | 3 (18.8) | 9 (56.2) | 4 (25) |
| Sigmoid | 16 | 7 (43.8) | 7 (43.8) | 2 (12.5) | 6 (60) | 4 (40) | 3 (30) | 3 (30) | 4 (40) | 2 (12.5) | 10 (62.5) | 4 (25) |
| Rectum | 10 | 1 (10) | 3 (30) | 6 (60) | 7 (43.8) | 9 (56.2) | 4 (25) | 7 (43.8) | 5 (31.2) | 3 (30) | 4 (40) | 3 (30) |
| Differentiationa | ||||||||||||
| WD MD | 24 13 | 6 (25) 4 (30.7) | 13 (54.1) 2 (15.3) | 5 (20.9) 7 (54) | 8 (33.3) 8 (61.5) | 16 (66.7) 5 (38.5) | 5 (20.8) 3 (23.1) | 5 (20.8) 5 (38.5) | 14 (58.3) 5 (38.5) | 7 (29.2) 2 (15.49 | 7 (29.2) 10 (76.9) | 10 (41.7) 1 (7.7) |
| PD | 13 | 2 (15.4) | 1 (7.7) | 10 (76.9) | 10 (76.9) | 3 (23.1) | 4 (30.8) | 8 (61.5) | 1 (7.7) | 1 ( 7.7) | 10 (76.9) | 2 (15.4) |
| Invasion | ||||||||||||
| T1 | 7 | 1 (14.3) | 1 (14.3) | 5 (71.4) | 1 (14.3) | 6 (85.7) | 2 (20) | 0 | 5 (71.4) | 2 (28.6) | 3 (42.9) | 2 (28.6) |
| T2 | 10 | 3 (30) | 3 (30) | 4 (40) | 6 (60) | 4 (40) | 2 (20) | (30) | 5 (50) | 1 (10) | 5 (50) | 4 (40) |
| T3 | 23 | 6 (26.1) | 7 (30.4) | 10 (43.5) | 15 (65.2) | 8 (34.8) | 5 (21.7) | 11 (47.8) | 7 (30.4) | 5 (21.7) | 5 (50) | 4 (17.4) |
| T4 | 10 | 2 (20) | 5 (50) | 3 (30) | 4 (40) | 6 (60) | 24 (30) | 18 (36) | 20 (40) | 2 (20) | 5 (50) | 3 (30) |
| LNMa | ||||||||||||
| Absent | 19 | 3 (15.8) | 13 (68.4) | 3 (15.8) | 6 (31.6) | 13 (68.4) | 5 (26.3) | 2 (10.5) | 12 (63.2) | 6 (31.6) | 5 (26.3) | 8 (42.1) |
| Present | 31 | 9 (29) | 3 (9.7) | 19 (61.3) | 20 (64.5) | 11 (35.5) | 7 (22.6) | 16 (88.9) | 8 (25.8) | 4 (12.9) | 22 (71) | 5 (16.1) |
| Lymphatic invasion | ||||||||||||
| Absent | 37 | 11(29.7) | 13 (35.1) | 13 (35.1) | 20 (54.1) | 17 (45.9) | 7(18.9) | 13 (35.1) | 17 (45.9) | 7 (18.9) | 24 (64.9) | 6 (16.2) |
| Present | 13 | 1 (7.7) | 3 (23.1) | 9 (69.2) | 6 (46.2) | 7 (53.8) | 5 (38.5) | 5 (38.5) | 3 (23.1) | 3 (23.1) | 3 (23.1) | 7 (53.8) |
| Vascular invasion | ||||||||||||
| Absent | 42 | 12(28.6) | 14(33.3) | 16 (38.1) | 23 (54.8) | 19 ( 45.2) | 8 (19) | 16 (38.1) | 18 (42.9) | 8 (19) | 25 (59.5) | 9 (21.4) |
| Present | 8 | 0 | 2 (25) | 6 (75) | 3 (37.5) | 5 (62.5) | 4 (50) | 2 (25) | 2 (25) | 2 (25) | 2 (25) | 4 (50) |
| Perineural invasion | ||||||||||||
| Absent present | 31 | 6 (19.4) | 12 (38.7) | 13 (41.9) | 15 (48.4) | 16 (51.6) | 8 (25.8) | 10 (32.3) | 13 (41.9) | 5 (16.1) | 17 (54.8) | 9 (29) |
| 19 | 6 (31.6) | 4 (21.1) | 9 (47.4) | 11 (57.9) | 8 (42.1) | 4 (21.1) | 8 (42.1) | 7 (36.8) | 5 (26.3) | 10 (52.6) | 4 (21.1) | |
| Stagea | ||||||||||||
| 1 + 2 | 24 | 8 (33.3) | 15 (62.5) | 9(4.2) | 7 (29.2) | 17 (70.8) | 5 (20.8) | 4 (16.7) | 15 (62.5) | 7 (29.2) | 9 (37.5) | 8 (33.3) |
| 3 + 4 | 26 | 4 (15.4) | 1(11.6) | 19(73) | 19 (73.1) | 7 (26.9) | 7 (26.9) | 14 (53.8) | 5 (19.1) | 3 (11.5) | 18 (69.2) | 5 (19.2) |
| Distant metastasis | ||||||||||||
| Absent | 26 | 7 (26.9) | 8 (30.8) | 11 (42.3) | 11 (42.3) | 15 (57.7) | 7 (26.9) | 7 (26.9) | 12 (46.2) | 4 (15.4) | 16 (61.5) | 6 (23.1) |
| Present | 24 | 12(20.8) | 8 (33.3) | 11 (45.8) | 15 (62.5) | 9 ( 37.5) | 5 (20.8) | 11 (45.8) | 8 (33.3) | 6 (25) | 11 (45.8) | 7 (39.2) |
| Survival (mo)a | ||||||||||||
| 60.62 ± 26.68 ≥ | 26 | 11 (42.3) | 0 | 15 (57.7) | 22 (84.6) | 4 (15.4) | 7 (26.9) | 15 (57.6) | 4 (42.4) | 4 (15.5) | 21 (80.7) | 1 (3.8) |
| 60.62 ± 26.68 < | 24 | 1 (4.2 ) | 16 (66.6 ) | 7 (29.2) | 4 (16.7) | 20 (83.3) | 5 (20.8) | 3 (12.5) | 16 (87.5) | 6 (25) | 6 (25) | 12 (50) |
a
P < 0.05. Downregulation of Notch and upregulation of Numb, Itch, and Siah-1 are associated with better prognosis. (↑): Upregulation, (↓): Downregulation; WD: Well-differentiated; MD: Moderately differentiated; PD: Poorly differentiated; LNM: Lymph node metastasis.