Table 4.
Sensitivity, specificity, positive and negative predictive value of anti-tissue transglutaminase antibodies and anti-deamidated gliadin peptide antibodies autoantibodies (with standard cutoff values according to laboratory references 18 U/mL for anti-tissue transglutaminase antibodies and 20 U/mL for anti-deamidated gliadin peptide antibodies) for prediction of villous atrophy in patients with celiac disease
| Characteristics | Sensitivity (%) (95%CI) | Specificity (%) (95%CI) | Accuracy (%) (95%CI) | Positive predictive value (%) (95%CI) | Negative predictive value (%) (95%CI) |
| Autoantibodies aTTG | 50.0 (26.0-74.0) | 85.7 (74.6-93.3) | 77.8 (67.2-86.3) | 50.0 (31.8-68.2) | 85.7 (78.9-90.6) |
| Autoantibodies aDGP | 77.8 (52.4-93.6) | 75.0 (62.1-85.3) | 75.6 (64.6-84.7) | 48.3 (36.1-60.7) | 91.8 (82.4-96.4) |
| Autoantibodies aTTG IgA | 50.0 (26.0-74.0) | 96.8 (89.0-99.6) | 86.4 (77.0-93.0) | 81.8 (51.6-95.0) | 87.1 (81.0-91.5) |
| Autoantibodies aTTG IgG | 5.6 (0.1-27.3) | 88.9 (78.4-95.4) | 70.4 (59.2-80.0) | 12.5 (1.8-52.1) | 76.7 (74.1-79.2) |
| Autoantibodies aDGP IgA | 72.2 (46.5-90.3) | 81.7 (69.6-90.5) | 79.5 (68.8-87.8) | 54.2 (39.2-68.4) | 90.7 (82.2-95.4) |
| Autoantibodies aDGP IgG | 61.1 (35.8-82.7) | 85.0 (73.4-92.9) | 79.5 (68.8-87.8) | 55.0 (37.6-71.2) | 87.9 (80.2-92.9) |
aTTG: Anti-tissue transglutaminase antibodies; aDGP: Anti-deamidated gliadin peptide antibodies; CI: Confidence interval.