Table 5.

Sensitivity, specificity, positive and negative predictive value of recalculated cutoff values of anti-tissue transglutaminase antibodies and anti-deamidated gliadin peptide antibodies autoantibodies titers and their combination with small bowel ultrasonography for prediction of villous atrophy in patients with celiac disease

Characteristics	Sensitivity (%) (95%CI)	Specificity (%) (95%CI)	Accuracy (%) (95%CI)	Positive predictive value (%) (95%CI)	Negative predictive value (%) (95%CI)
Autoantibodies aTTG IgA (cutoff: 13.4)	66.7 (41.0-86.7)	93.7 (84.5-98.2)	87.7 (78.5-93.9)	75.0 (52.4-89.1)	90.8 (83.6-95.0)
Autoantibodies aTTG IgG (cutoff: 6.7)	33.3 (13.3-59.0)	87.3 (76.5-94.4)	75.3 (64.5-84.2)	42.9 (23.0-65.3)	82.1 (76.5-86.6)
Autoantibodies aDGP IgA (cutoff: 22.6)	72.2 (46.5-90.3)	90.0 (79.5-96.2)	85.9 (76.2-92.7)	68.4 (49.1-83.0)	91.5 (83.6-95.8)
Autoantibodies aDGP IgG (cutoff: 28.8)	61.1 (35.8-82.7)	90.0 (79.5-96.2)	83.3 (73.2-90.8)	64.7 (44.1-81.0)	88.5 (81.1-93.3)
Autoantibodies aTTG IgA (cutoff 13.4) AND ultrasonography	47.1 (23.0-72.2)	98.0 (89.2-99.9)	84.9 (73.9-92.5)	88.9 (51.9-98.3)	84.2 (77.3-89.3)
Autoantibodies aDGP IgA (cutoff 22.6) AND ultrasonography	52.9 (27.8-77.0)	97.8 (88.5-99.9)	85.7 (74.6-93.3)	90.0 (55.2-98.5)	84.9 (77.2-90.3)

aTTG: Anti-tissue transglutaminase antibodies; aDGP: Anti-deamidated gliadin peptide antibodies; CI: Confidence interval.