Table 3.
Correlation of enhanced liver fibrosis (ELF) score and its single components with hepatic venous pressure gradient (HVPG)
| Selection | Parameter | Rho | 95%CI | P‐value |
|---|---|---|---|---|
| Overall (N = 201) | ELF | 0.443 | 0.321‐0.551 | <.001 |
| TIMP1 | 0.368 | 0.238‐0.485 | <.001 | |
| PIIINP | 0.332 | 0.199‐0.453 | <.001 | |
| HA | 0.419 | 0.294‐0.530 | <.001 | |
| ALD (N = 83) | ELF | 0.281 | 0.063‐0.473 | .010 |
| TIMP1 | 0.235 | 0.014‐0.434 | .033 | |
| PIIINP | 0.213 | −0.010 to 0.415 | .053 | |
| HA | 0.283 | 0.065‐0.475 | .010 | |
| VIRAL (N = 40) | ELF | 0.449 | 0.151‐0.673 | .004 |
| TIMP1 | 0.279 | −0.045 to 0.550 | .081 | |
| PIIINP | 0.328 | 0.009‐0.586 | .039 | |
| HA | 0.488 | 0.200‐0.699 | .001 | |
| OTHER (N = 78) | ELF | 0.391 | 0.178‐0.569 | <.001 |
| TIMP1 | 0.323 | 0.102‐0.514 | .004 | |
| PIIINP | 0.197 | −0.034 to 0.407 | .084 | |
| HA | 0.402 | 0.191‐0.578 | <.001 | |
| HVPG 6‐9 (N = 24) | ELF | 0.569 | 0.203‐0.796 | .004 |
| TIMP1 | −0.147 | −0.529 to 0.284 | .493 | |
| PIIINP | 0.559 | 0.189‐0.790 | .005 | |
| HA | 0.475 | 0.076‐0.743 | .019 | |
| HVPG 10‐19 (N = 112) | ELF | 0.304 | 0.120‐0.468 | .001 |
| TIMP1 | 0.247 | 0.058‐0.418 | .009 | |
| PIIINP | 0.273 | 0.087‐0.441 | .004 | |
| HA | 0.268 | 0.081‐0.437 | .004 | |
| HVPG ≥ 20 (N = 65) | ELF | −0.023 | −0.273‐0.229 | .853 |
| TIMP1 | 0.020 | −0.232 to 0.270 | .874 | |
| PIIINP | −0.105 | −0.347 to 0.149 | .404 | |
| HA | 0.021 | −0.231 to 0.271 | .867 | |
| Child‐A (N = 116) | ELF | 0.450 | 0.286‐0.588 | <.001 |
| TIMP1 | 0.261 | 0.077‐0.438 | .005 | |
| PIIINP | 0.237 | 0.052‐0.407 | .010 | |
| HA | 0.471 | 0.311‐0.605 | <.001 | |
| Child‐B/C (N = 85) | ELF | 0.014 | −0.206 to 0.233 | .896 |
| TIMP1 | 0.129 | −0.093 to 0.338 | .241 | |
| PIIINP | −0.003 | −0.222 to 0.216 | .979 | |
| HA | −0.009 | −0.227 to 0.211 | .938 | |
| cACLD (N = 85) | ELF | 0.517 | 0.335‐0.661 | <.001 |
| TIMP1 | 0.227 | 0.062‐0.468 | .010 | |
| PIIINP | 0.291 | 0.076‐0.479 | .007 | |
| HA | 0.535 | 0.358‐0.675 | <.001 | |
| dACLD (N = 116) | ELF | 0.113 | −0.076 to 0.294 | .227 |
| TIMP1 | 0.186 | −0.002 to 0.361 | .046 | |
| PIIINP | 0.045 | −0.144 to 0.231 | .633 | |
| HA | 0.127 | −0.062 to 0.307 | .174 |
Abbreviations: 95%CI, 95% confidence interval; ALD, Alcohol‐related liver disease; cACLD, compensated advanced chronic liver disease; dACLD, decompensated advanced chronic liver disease; ELF, enhanced liver fibrosis score; HA, hyaluronic acid; HVPG, hepatic venous pressure gradient; PIIINP, Amino‐terminal propeptide of type III procollagen; Rho, Spearman's Rho; TIMP‐1, Tissue inhibitor matrix metalloproteinase‐1.
P‐values < .05 are indicated in bold.