Table 2.

The inhibition of human AspH by C‐3 aminoalkyl‐substituted 2,4‐PDCA derivatives.

	Compound	IC50 [μM][a]
1	18	0.58 ±0.06
2	25	3.95 ±0.33
3	26	7.66 ±1.45
4	27	10.91 ±1.83
5	28	10.76 ±0.28
6	29	0.28 ±0.11
7	30	1.22 ±0.26
8	31	1.86 ±1.06
9	32	3.67 ±0.74
10	33	13.13 ±4.84

[a] Mean average of two independent runs (n=2; mean ± SD). AspH inhibition assays were performed as described in the Experimental Section by using 50 nM His₆‐AspH_315‐758 and 1.0 μM hFX‐CP_101‐119 (Figure 2D) as a substrate.