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. 2020 May 22;63(14):7601–7615. doi: 10.1021/acs.jmedchem.0c00418

Table 1. Kinetic Binding Constants for the Interaction between PSMA and the NBs, As Measured by SPRa.

NB Kon [M–1 s–1] Koff [s–1] KD [nM]
NB7 (7.1 × 105) ± (4.5 × 102) (3.9 × 10–5) ± (2.8 × 10–7) 0.055
NB8 (2.0 × 104) ± (4.2 × 101) (1.2 × 10–4) ± (5.3 × 10–7) 6.0
NB13 (3.6 × 104) ± (8.9 × 101) (2.2 × 10–5) ± (9.9 × 10–7) 0.60
NB37 (2.2 × 104) ± (5.3 × 101) (7.5 × 10–5) ± (6.6 × 10–7) 3.4
a

Values represent the mean ± SD.