. 2020 Jun 24;63(14):7740–7765. doi: 10.1021/acs.jmedchem.0c00570

Table 1. Effect of Changing Core Structures on Enzyme- and Cell-Based Activities^b.

graphic file with name jm0c00570_0009.jpg

Selectivity = IC₅₀ (HsNMT1)/IC₅₀ (LdNMT). LipE = pIC₅₀ – clog P; where values for LdNMT and LmNMT were obtained, the average LipE is reported. EC₅₀ for intracellular L. donovani amastigotes.

Toxicity against bone-marrow-derived macrophages; nAUC, normalized area under the curve. The dose–response curves are shown in Figures S6–S10.

Table 1. Effect of Changing Core Structures on Enzyme- and Cell-Based Activitiesb.

Table 1. Effect of Changing Core Structures on Enzyme- and Cell-Based Activities^b.