. 2020 Jun 24;63(14):7740–7765. doi: 10.1021/acs.jmedchem.0c00570

Table 3. Effect of Changing C₄ and C₂ Substitutions on Enzyme- and Cell-Based Activities (Compounds 31–49)^a.

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95% CI = 95% confidence interval. Selectivity = IC₅₀ (HsNMT)/IC₅₀ (LdNMT). LipE = pIC₅₀ – clog P; where values for LdNMT and LmNMT were obtained, the average LipE is reported. nAUC, normalized area under the curve. The dose–response curves are shown in Figures S6–S10.

Table 3. Effect of Changing C4 and C2 Substitutions on Enzyme- and Cell-Based Activities (Compounds 31–49)a.

Table 3. Effect of Changing C₄ and C₂ Substitutions on Enzyme- and Cell-Based Activities (Compounds 31–49)^a.