. 2020 Jun 24;63(14):7740–7765. doi: 10.1021/acs.jmedchem.0c00570

Table 4. Effect of Changing C₂ and C_6/7 Substitutions and Fragment Merging on Enzyme- and Cell-Based Activities (Compounds 50–67).

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95% CI = 95% confidence interval. Selectivity = IC₅₀ (HsNMT)/IC₅₀ (LdNMT). LipE = pIC₅₀ – log P; where values for LdNMT and LmNMT were obtained, the average LipE is reported. nAUC, normalized area under the curve. The dose–response curves are shown in Figures S6–S10.

Table 4. Effect of Changing C2 and C6/7 Substitutions and Fragment Merging on Enzyme- and Cell-Based Activities (Compounds 50–67).

Table 4. Effect of Changing C₂ and C_6/7 Substitutions and Fragment Merging on Enzyme- and Cell-Based Activities (Compounds 50–67).