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. Author manuscript; available in PMC: 2020 Jul 27.
Published in final edited form as: J Invest Dermatol. 2016 May 5;136(7):1316–1318. doi: 10.1016/j.jid.2016.04.019

Figure 1.

Figure 1.

A keratinocyte in an advanced stage of transformation from a granular cell to a corneocyte. Lysosomes/autophagosomes (L) are present in the cytoplasm. Filaggrin (K) is spread throughout the cytoplasm intermingling with keratin filaments (F). The thickened, modified corneocyte envelope (PM) is tightly attached to the lower granular cell. The nucleus (N), last of the recognizable organelles, shows signs of degradation. Reprinted from ©Lavker and Matoltsy, 1970, J Cell Biology, 44:501–512