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. 2020 Jun 2;15(13):1175–1186. doi: 10.1002/cmdc.202000180

Table 3.

Metabolic stability of azocarboxamides 9 b and 18 and cinnamides 16 b and 19 in the presence of rat liver microsomes.

graphic file with name CMDC-15-1175-g009.jpg

Compound

Half‐life[a] [min]

Intrinsic clearance[a] [μL×min−1×mg−11]

9 b

166±16

42±4

16 b

252±94

28±5

18

73±12

97±15

19

85±18

85±20

20

52±6

132±4

[a] The metabolic stability was determined via the half‐life and the intrinsic clearance, which were calculated depending on the amount of rat microsomes that was used (see Supporting Information).