Table 3.
Metabolic stability of azocarboxamides 9 b and 18 and cinnamides 16 b and 19 in the presence of rat liver microsomes.
| ||
---|---|---|
Compound |
Half‐life[a] [min] |
Intrinsic clearance[a] [μL×min−1×mg−11] |
9 b |
166±16 |
42±4 |
16 b |
252±94 |
28±5 |
18 |
73±12 |
97±15 |
19 |
85±18 |
85±20 |
20 |
52±6 |
132±4 |
[a] The metabolic stability was determined via the half‐life and the intrinsic clearance, which were calculated depending on the amount of rat microsomes that was used (see Supporting Information).