Table 1.
Vascular responses to targeted PDT.
| Tumors | Prior to | 5 min | 2 h | 24 h | 48 h |
|---|---|---|---|---|---|
| Tumor‐1 | − | − | + | ++ | − |
| Tumor‐2 | − | − | + | ++ | − |
| Tumor‐3 | − | + | + | − | − |
| Tumor‐4 | − | − | + | − | − |
EGFR‐overexpressing human head and neck OSC‐19‐luc2‐cGFP tumor in the mouse skin‐fold window chamber was irradiated with a 690 nm laser at a dose of 100 J cm−2 (50 mW cm−2) at 24 h after the i.v. injection of Cetuximab‐IR700DX conjugate.
The vascular responses were semiquantified by (−) no changes in the vascular lumen with normal blood flow, (+) slight changes in narrowing or dilating the vascular lumen, but still with visible blood flow and (++) severely changes in narrowing the vascular lumen and/or shutting down the vessels with no detectable blood flow.