Figure 2.

(a) Regenerative mechanisms of the damage response enhancer for Drosophila wing imaginal discs; Wg and Wnt6 expression are upregulated in response to damage via the damage response enhancer in unmatured discs. In contrast, immediately adjacent regulatory elements promote methylation of H3K27me3 across the Wnt gene cluster. This methylation event prevents regeneration of wing imaginal discs. The image was adapted and modified from Harris et al., (2016). (b) Genomic DNA regions surrounding the lepb gene and profiles of H3K27ac in uninjured and regenerating hearts; transgenic analyses showed that H3K27ac‐rich elements have enhancer activity in regenerating zebrafish hearts