FIGURE 1.

(a) Genetic organization of the esx‐5 loci in M. marinum and in M. tuberculosis. The shared identities of the orthologous proteins encoded by the genes are indicated. (b) General domain architecture of mycobacterial EccC ATPases. The constructs contain: TM, transmembrane domains; DUF, domain of unknown function, shown to adopt an ATPase fold for EccC₃ (Famelis et al., 2019; Poweleit et al., 2019); NBD, nucleotide binding domain. (c) Structural model of the M. marinum EccC₅ ATPase domains (residues 432–1388), generated with Phyre2 using the structure of T. curvata EccC as a template. The missing 65 residues of the linker 2 region that could not be modeled are indicated in red