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. 2020 May 22;184(2):226–238. doi: 10.1002/ajmg.c.31800

FIGURE 2.

FIGURE 2

Sex differences in expression for genes in the PARs or that escape from XCI. The genes shown are ones which have been shown to escape from XCI in multiple studies. At the left, a schematic shows the location of the PARs and genes escaping XCI. The number of tissues in GTEx (out of 29) with expression and sex bias per gene are shown (center left). The XX/XY expression ratio per gene for the tissues in GTEx (a) with the most expression, the most biased expression, or averaged for the significantly sex‐biased tissues. The final two columns show matched XX/XY and XXY/XY ratios for lymphoblastoid cell lines (b) from Raznahan et al. (2018) (center right). The number of other studies with significant XXY/XY expression per gene (out of four studies: Belling et al., 2017; Skakkebæk et al., 2018; Zitzmann et al., 2015; Zhang et al., 2020) is shown to the right. Genes with Y homology are shown in blue, with those outside the PARs in bold font