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. 2020 May 11;47(8):1484–1494. doi: 10.1111/1440-1681.13320

FIGURE 3.

FIGURE 3

Rotenone inhibited PI3K/AKT pathway in LoVo and SW480 cells. LoVo and SW480 cells were divided into control, veh, and rotenone groups (Rot‐10 μg/mL, Rot‐100 μg/mL and Rot‐1000 μg/mL). A and B, The protein levels of p‐PI3K, PI3K, p‐AKT, and AKT were detected by western blot. C and D, AKT downstream signal molecules IKK, TSC1 and GSK3 mRNA expressions were detected by RT‐PCR P > .05, P < .05, **P < .01, ***P < .001 vs veh group. A‐D, Inline graphic, control; Inline graphic, veh; Inline graphic, Rot‐10 μg/mL; Inline graphic, Rot‐100 μg/mL; Inline graphic, Rot‐1000 μg/mL