Table 2.

Group Comparisons between Down Syndrome (DS) and Controls (CTR) Subjects based on Mixed‐Effects Regression Model with Multiple Comparison Adjustments

Group Comparisons	p‐value
CTR CX <40 vs. DS CX ≥40	<.0001	<.0001	<.0001	<.0001
CTR CX <40 vs. DS HC ≥40	0.0003	<.0001	0.0094	<.0001
CTR CX ≥40 vs. DS CX ≥40	<.0001	<.0001	<.0001	<.0001
CTR CX ≥40 vs. DS HC ≥40	0.0002	<.0001	0.0601	<.0001
CTR HC <40 vs. DS CX ≥40	<.0001	<.0001	<.0001	<.0001
CTR HC <40 vs. DS HC ≥40	<.0001	<.0001	0.0169	<.0001
CTR HC ≥40 vs. DS CX ≥40	<.0001	<.0001	<.0001	<.0001
CTR HC ≥40 vs. DS HC ≥40	<.0001	<.0001	0.0007	<.0001
DS CX <40 vs. DS CX ≥40	<.0001	<.0001	0.0002	<.0001
DS CX <40 vs. DS HC ≥40	0.0004	<.0001	0.2261	<.0001
DS CX ≥40 vs. DS HC <40	<.0001	<.0001	<.0001	<.0001
DS CX ≥40 vs. DS HC ≥40	<.0001	0.0661	0.0219	0.0002
DS HC <40 vs. DS HC ≥40	0.003	<.0001	0.0543	<.0001

CTR = control; DS = Down syndrome; CX = cortex; HC = hippocampus. Age = <40 years; ≥40 years.