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. 2020 May 6;40(7):1655–1669. doi: 10.1111/liv.14490

Figure 5.

Figure 5

Chronic administration of OCA but not EDP‐305 induces mild ductular proliferation in livers of healthy wild‐type mice. Six‐week‐old wild‐type C57B16 mice received EDP‐305 or OCA‐supplemented diets (at 30 mg/kg/day dose equivalent) or control diet (Placebo) for 1 or 2 weeks. (A) Serum levels of transaminases (ALT, AST), TBIL and total bile acids. (B) Representative stainings for ductular markers CK19, integrin αvβ6, SOX9 and laminin (50x and x200 blow‐ups as indicated). (C) Quantification of CK19‐positive cells (n = 5). (D) Hepatic transcript levels of ductular/hepatic progenitor cell markers CK19, EpCAM, TROP2 and ITGB6, as measured by TaqMan qRT‐PCR. Data are mean ± SEM. *P < .05 compared to placebo control group (ANOVA with Dunnett's post‐test)