Figure 2.

High expression of KIF11 is related to invasiveness in breast cancer in downloaded datasets. A, The mRNA levels of KIF11 and age, tumor size, ER status, and Elson grade of breast cancer in pooled dataset in non‐TCGA. Here, the KIF11‐high was defined as the KIF11 mRNA level equal to or larger than median mRNA levels in each dataset. B, The mRNA levels of KIF11 and age, tumor size, ER status, and Elson grade of breast cancer in pooled dataset in TCGA. C, The mRNA expression level of KIF11 in different molecular subtypes of breast cancer in TCGA‐BRCA‐set2. D, Genes were coexpressed with KIF11 in TCGA‐BRCA‐set2. E, Enriched gene signatures associated with poor prognosis were displayed. Heatmap depicts the expression levels of these genes. Red represents upregulation, and blue represents downregulation. F, NES of KIF11 shown in a related pathway in ordered datasets. ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; KIF11, kinesin family member 11; LumA, luminal A; LumB, luminal B; mRNA, messenger RNA; NES, normalized enrichment score; TCGA‐BRCA, The Cancer Genome Atlas‐Breast Invasive Carcinoma; TNBC, triple‐negative breast cancer [Color figure can be viewed at wileyonlinelibrary.com]