Table 1.

Patient characteristics and clinical manifestations (n = 2)

Patient	Sex	Age (y)	Diagnosis	Skin at birth	Skin present	Hair	Atopic manifestation	Serum IgE (IU/mL)	BSA	IGA	TLSS	Age of improvement
1	M	43	Genetic	ED	ED	TI, short, easily broken	Rhinitis, food allergy	22	Total	4	E3I2L2	None
2	F	46	Genetic	Other	ILC + ED	TI	Asthma, rhinitis, atop. dermatitis, food allergy	159	>50%	2	E1I1L0	None
3	M	21	Genetic	ED	ILC + ED	TI, easily broken	Atop. dermatitis, food allergy	>5000	Total	4	E3I3L2	None
4	F	9	Genetic	Normal	ILC + ED	TI, short	Rhinitis, food allergy	4524	Total	4	E1I1L2	None
5	F	8	Genetic	Other	ED	TI, short, easily broken	Asthma, rhinitis, food allergy	>5000	Total	4	E3I3L3	1.5 y
6	F	24	Genetic	ED	ILC + ED	TI, short, easily broken	Rhinitis, food allergy	4083	>75%	3	E3I3L2	5 y
7	F	22	Genetic	ED	ILC + ED	TI	Food allergy	>5000	Total	3	E2I2L2	None
8	M	24	Genetic	ED + ILC	ILC	TI, easily broken	Asthma, rhinitis, atop. dermatitis, food allergy	>5000	>75%	3	E2I2L2	12 y
9	M	36	Genetic	Normal	ILC	TI	None	>5000	Total	2	E2I1L2	None
10	F	6	Genetic	ED	ILC + ED	TI, short, easily broken	Asthma, rhinitis, atop. dermatitis, food allergy	Not available	>50%	3	E2I3L3	1 y
11	F	3	Genetic	ED	ILC + ED	TI	Atop. dermatitis, food allergy	>5000	<50%	3	E2I1L1	1 y
12	M	39	Genetic	ED	ILC + ED	TI, short easily broken	Asthma, rhinitis, atop. dermatitis, food allergy	3522	>50%	3	E1I2L3	12 y
13	M	43	Genetic	ED	ILC	TI	Asthma, rhinitis, atop. dermatitis, food allergy	136	<25%	Not available	Missing	14 y
14	M	36	Genetic	ED	ILC	TI, easily broken	Asthma, rhinitis, atop. dermatitis, food allergy	>5000	>50%	2	E2I2L0	25 y

Abbreviations: BSA, body surface area; ED, erythroderma; IGA, Investigator's Global Assessment; ILC, ichthyotic linearis circumflexa; TI, trichorrhexis invaginata; TLSS, total lesional sign score (see also Table S1).