TABLE 1.
Growth, development, and behavior in the 42 individuals with Primrose syndrome
| Children | Adults | All | |
|---|---|---|---|
| n = 29 | n = 13 | n = 42 | |
| Growth at birth | |||
| Length (cm) | 49.7 ± 3.60 | ||
| Length > 2SD | 1/22 | ||
| Weight (kg) | 3.19 ± 0.64 | ||
| Weight > 2SD | 3/29 | ||
| Head circumference (cm) | 35.91 ± 2.25 | ||
| Head circumference > 2SD | 9/22 | ||
| Postnatal growth | |||
| Mean age at last clinical evaluation (y) | 7.74 ± 4.22 | 37.38 ± 10.34 | 17.80 ± 15.6 |
| Height (cm) | 125.83 ± 29.33 | 177.50 ± 10.71 | |
| Height > 2SD | 3/25 (12%) | 0/9 (0%) | 3/34 (9%) |
| Weight (kg) | 31.91 ± 22.45 | 72.80 ± 16.09 | |
| Weight > 2SD | 6/25 (24%) | 0/6 (0%) | 6/31 (19%) |
| Head circumference (cm) | 54.71 ± 3.69 | 58.75 ± 2.46 | |
| Head circumference > 2SD | 21/26 (81%) | 8/12 (67%) | 29/38 (76%) |
| Development | |||
| Intellectual disability mild | 5/27 (19%) | 2/13 (15%) | 7/39 (18%) |
| Intellectual disability moderate‐severe | 22/27 (81%) | 11/13 (85%) | 33/39 (85%) |
| Behavior | |||
| Autism | 16/24 (67%) | 4/9 (44%) | 20/33 (61%) |
| Self‐injurious behavior | 7/19 (37%) | 4/7 (57%) | 11/26 (42%) |
| Sleep disturbances | 8/19 (42%) | 2/7 (29%) | 10/26 (38%) |
Note: Only data of at term born newborns (38‐42 wk) have been used.