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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Vet Comp Oncol. 2019 Oct 15;18(1):64–75. doi: 10.1111/vco.12529

Table 3:

Comparison of cytokine profiles from human and canine macrophages under different culture conditions.

Macrophages alone (M) Macrophages + OS (M+O) Macrophages + OS + S. aureus (M+O+SA) Macrophage subset predominantly secreting cytokine listed
IFN-γ (human) ↑ vs. M *↑ vs. M
*↑ vs. M+O 		M1
IFN-γ (canine) ↑ vs. M *↑ vs. M
↑ vs. M+O 		M1
TNF-α (human) ↑ vs. M *↑ vs. M
*↑ vs. M+O 		M1
TNF-α (canine) *↑ vs. M *↑ vs. M
*↑ vs. M+O 		M1
MCP-1 (human) *↓ vs. M+O
*↓ vs. M+O+SA 		↓ vs. M+O+SA
 M1
MCP-1 (canine) *↓ vs. M+O
*↓ vs. M+O+SA 		↑ vs. M+O+SA M1
Il-12p70 (human) No difference from M *↑ vs. M
*↑ vs. M+O 		M1
IL-12p40 (human) ↑ vs. M *↑ vs. M
↑ vs. M+O 		M1
IL-10 (human) *↓ vs. M+O
*↓ vs. M+O+SA 		↓ vs. M+O+SA
 M2
IL-10 (canine) *↑ vs. M *↑ vs. M
*↑ vs. M+O 		M2
TGF-β (human) ↑ vs. M *↓ vs. M
*↓ vs. M+O 		M2
TGF-β (canine) ↑ vs. M *↓ vs. M
*↓ vs. M+O 		M2

Arrows indicate an increase or decrease when comparing macrophages from the indicated culture group to another culture group (significant differences marked with an asterisk). M = macrophages cultured alone, M+O = macrophages cultured with OS, M+O+SA – macrophages cultured with OS and S. aureus.