Table 2:
Multivariable adjusted odds ratios of presenting with advanced disease (T3-T4 or N2-N3) among N=4,735 patients with M0 HNSCC
| Characteristic | Early Stage (N=1,246) | Advanced Stage (N=3,489) | Odds of Advanced Stage | ||
|---|---|---|---|---|---|
| AOR (95% CI) | P | ||||
| HNSCC Subsite, N (Percent) | |||||
| Non-Oropharynx | 248 (19.9) | 351 (10.1) | 1.0 (Referent) | ||
| Oropharynx | 998 (80.1) | 3138 (89.9) | 2.31 (1.91–2.80) | <0.001 | |
| HPV Status | |||||
| HPV-negative | 452 (36.3) | 1021 (29.3) | 1.0 (Referent) | ||
| HPV-positive | 794 (63.7) | 2468 (70.7) | 1.22 (1.05–1.42) | 0.10 | |
| Race, N (Percent) | |||||
| White | 1091 (87.6) | 2947 (84.5) | 1.0 (Referent) | ||
| Non-White | 155 (12.4) | 542 (15.5) | 0.68 (0.57–0.81) | <0.001 | |
| Age at Diagnosis, Median (IQR) | |||||
| Sex, N (Percent) | |||||
| Female | 258 (20.7) | 508 (14.6) | 1.0 (Referent) | ||
| Male | 988 (79.3) | 2981 (85.4) | 1.50 (1.26–1.78) | <0.001 | |
| Insurance Status, N (Percent) | |||||
| Private or Other Insurance | 1055 (84.7) | 2871 (82.3) | 1.0 (Referent) | ||
| Uninsured | 33 (2.6) | 116 (3.3) | 1.18 (0.79–1.78) | 0.42 | |
| Medicaid | 127 (10.2) | 461 (13.2) | 1.33 (1.06–1.66) | 0.01 | |
| Unknown | 31 (2.5) | 41 (1.2) | 0.44 (0.26–0.72) | 0.001 | |
| Smoking Propensity,b Median (IQR) | 40.4 (33.5–44.9) | 40 (33.3–44.6) | 0.99 (0.98–1.00) | 0.19 | |
| Percent High School Education,c Median (IQR) | 87.0 (82.3–89.7) | 87.0 (83.1–89.8) | 1.01 (1.00–1.06) | 0.18 | |
| Household Income,c Median (IQR) | 56,600 (48,700–71,380) | 59,740 (50,310–71,020) | 1.00 (1.00–1.00) | 0.94 | |
| Marital Status, N (Percent) | |||||
| Married | 770 (61.8) | 1966 (56.3) | 1.0 (Referent) | ||
| Single | 201 (16.1) | 685 (19.6) | 1.28 (1.06–1.54) | 0.01 | |
| Divorced/Widowed/Separated | 210 (16.9) | 673 (19.3) | 1.38 (1.15–1.66) | 0.001 | |
| Unknown | 65 (5.2) | 165 (4.7) | 1.16 (0.84–1.60) | 0.36 | |