. Author manuscript; available in PMC: 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun 1;2(7):612–619. doi: 10.1038/s42255-020-0212-y

Table 1|.

Recommendations delivered by the KNN-DSS engine.

Recommendation	Message to User	Adjustment Window	Titration Method
Basal Adjustment	“You may need (less/more) basal insulin. It is recommended that you (decrease/increase) your AAA insulin from BBB to CCC units.	AM PM	Adjustment by +/− 10% from weekly baseline settings
Carb:ins Ratio	“You may need (less/more) insulin before (breakfast/lunch/dinner/a meal). It is recommended that you change your carb ratio from AAA to BBB.”	7:00 – 11:00 11:00 – 15:00 15:00 – 20:00 20:00 – 7:00	ALPHA Algorithm: meal bolus glycaemic response and assignment of dosage titration.
Correction Factor	“You may need (less/more) insulin in (morning / afternoon / evening / nighttime) to bring down high glucose levels. It is recommended that you change your correction factor from AAA to BBB.”	7:00 – 11:00 11:00 – 15:00 15:00 – 20:00 20:00 – 7:00	ALPHA Algorithm: correction bolus glycaemic response and assignment of dosage titration.
Bolus Adherence^a	“You may have taken (more/less) insulin than recommended by the bolus calculator during certain times of day. It is recommended that you use the amount recommended by the bolus calculator”	All Day	N/A
Basal Adherence ^a	“We have found that the amount of basal insulin that you are taking is different than the amount we recommend. Taking the recommended amount may improve your glucose levels.”	All Day	N/A

Recommendations for insulin dosage are titrated to be higher or lower during different time windows using the specified titration method.

Behavioral recommendation.