Extended Data Fig. 2.

Structures of inhibitors and pathways of NRH metabolism. a) Structures of AK inhibitors. b) The “NRH salvage pathway”, where NRH is transported across cell membrane, phosphorylated into NMNH by NRH kinase, then adenylated into NADH which is then oxidized to produce NAD+. Additional pathways such as nicotinamide salvage, dependent upon Nampt (FK866 sensitive) and Nrk1 dependent pathways are also depicted in the unshaded part of the Scheme. Modified from Scheme published in reference 35.