Table 2. Reaction conditions and optimisation for the synthesis of [¹¹C]1 using BEMP as a trapping agent (see footnote ‡).

Entry a	KF (eq.)	K2.2.2 (eq.)	BEMP (eq.)	CuI (%)	TE (%)	RCY [11C]1 (%)
1 b	0.25	0.25	0.6	10	84 ± 3	33 ± 15
2	0.25	0.25	0.6	10	89 ± 8	93 ± 6
3 c	0.25	0.25	0.6	10	76 ± 12	58 ± 9
4	0.25	0.25	—	10	6 ± 2	95 ± 1
5	0.25	0.25	0.6	—	76 ± 22	24 ± 18
6 d	—	0.25	0.6	10	40, 30	0
7 e	0.25	—	0.6	10	48	0
8 f	0.125	0.125	0.6	10	55 ± 15	47 ± 9
9 g	0.25	0.25	0.6	10	12 ± 5	20 ± 7
10 e , h	0.25	0.25	0.6	10	50	0

^a n = 3.

^b100 °C.

^c2.5 minutes.

^d n = 2.

^e n = 1.

^f 1a (50 μmol).

^gTHF.

^hMeCN.