Table 1.
Demographics and Baseline Biomarkers Overall and by Immune Reconstitution Inflammatory Syndrome Event
| Demographic | All Participants | IRIS | Non-IRIS | P Value | |
|---|---|---|---|---|---|
| Number of participants (%) | 506 (100) | 97 (19.2) | 409 (80.8) | ||
| Site | Kenya | 200 (39.5) | 33 (34.0) | 167 (40.8) | .1621 |
| Thailand | 100 (19.8) | 16 (16.5) | 84 (20.5) | ||
| United States | 206 (40.7) | 48 (49.5) | 157 (38.6) | ||
| Sex | Female | 199 (39.3) | 37 (38.1) | 162 39.6) | .8181 |
| Male | 307 (60.7) | 60 (61.9) | 247 (60.4) | ||
| Age, y | 37 (31–45) | 37 (30–44) | 37 (32–46) | .3662 | |
| Body mass index (kg/m2) | 20.24 (17.90–23.48) | 19.70 (17.80, 23.09) | 20.49 (17.90, 23.49) | .4171 | |
| White blood cell count (106/µL) | 3.25 (2.47–4.30) | 3.21 (2.37–4.98) | 3.25 (2.5–4.3) | .4535 | |
| Hemoglobin (g/dL) | 10.9 (9.6–12.4) | 10.0 (8.80–11.2) | 11.20 (9.8–12.7) | <.0001 | |
| Platelets (106/µL) | 221 (162, 289) | 219 (172.0, 303.5) | 221 (161.0, 285.0) | .7233 | |
| Glucose (mg/dL) | 85 (76.86, 95.00) | 85 (76.32, 96.15) | 85 (77.00, 94.68) | .7534 | |
| CD4 T cells/µL | 29 (11–56) | 22 (7–49) | 30 (12–58) | .0358 | |
| CD8 T cells/µL | 458 (273–740) | 384 (237, 656) | 476 (279, 747) | .0456 | |
| Human immunodeficiency virus RNA (copies/mL) | 5.30 (4.89–5.70) | 5.37 (5.06–5.70) | 5.28 (4.87–5.70) | .0491 | |
| D-dimer (µg/mL) | 1.04 (0.62, 2.12) | 1.56 (0.89, 3.32) | 0.99 (0.58, 1.84) | <.0001 | |
| C-reactive protein (µg/mL) | 5.01 (1.26, 16.69) | 9.14 (4.19, 30.06) | 4.07 (1.17, 14.57) | .0003 |
Median values are included with interquartile range or percentage. For continuous variables, we used the Wilcoxon rank sum test. For discrete variables, we used the Fisher exact test.
Abbreviation: IRIS, immune reconstitution inflammatory syndrome.