Figure 1:

A “boiled egg plot”, adapted from Daina & Zoete (5), relating lipophilicity (WLOGP) to polar properties (TPSA) of molecules as calculated by the SwissADME website (4). Different forms of steroids have markedly different physical properties which influence their passage through membranous boundaries of the body. For intratympanic applications, these properties affect both entry into the ear and elimination from the ear to the vasculature, both of which involve passage through membranous cellular boundaries.