▮Table 2▮.
Comparison of GS-1 and GS-2 in Cases Demonstrating TCR-Vβ Restriction*
Diagnosis/Case No. | TCR−Vβ Family | GS−1: Vβ−Restricted Gated Cells (%) | GS−2: Vβ−Restricted Gated Cells (%) | Clonality by TCR PCR |
---|---|---|---|---|
ATLL | ||||
3 | 8 | 30.16 | 60.49 | + |
6 | 9 | 54.54 | 58.32 | + |
7 | 22 | 86.45 | 89.13 | + |
8 | 17 | 18.4 | 77.46 | + |
10 | 1 | 28.49 | 84.53 | + |
11 | 1 | 9.2 | 67.86 | + |
12 | 1 | 54.42 | 82.84 | + |
14 | 22 | 69.09 | 81.83 | + |
15 | 18 | 86.04 | 92.06 | + |
16 | 17 | 95.45 | 98.23 | + |
17 | 5.1 | 98.02 | † | + |
19 | 17 | 53.6 | 70.75 | + |
21 | 5.1 | 87.91 | 98.37 | + |
22 | 9 | 6.72 | 63.05 | + |
24 | 13.1 | 80.19 | 83.56 | ND |
CTCL | ||||
26 | 21.3 | 91.71 | 97.91 | + |
28 | 8 | 92.02 | 98.60 | + |
29 | 14 | 99.31 | † | ND |
30 | 13.2 | 87.0 | 92.70 | + |
31 | 20 | 97.78 | † | ND |
PTCL | ||||
32 | 4 | 53.06 | 86.67 | + |
33 | 17 | 80.94 | 98.68 | + |
34 | 17 | 91.27 | 95.15 | + |
TPLL | ||||
35 | 13.1 | 93.79 | 98.00 | + |
LGL | ||||
36 | 3 | 63.58 | ‡ | + |
39 | 7.1 | 98.45 | † | + |
40 | 8 | 97.49 | † | + |
ATLL, human T-lymphotropic virus-1–associated adult T-cell leukemia/lymphoma; CTCL, cutaneous T-cell lymphoma; GS-1, gating strategy 1; GS-2, gating strategy 2; LGL, T-cell large granular lymphocytic leukemia; ND, not done; PCR, polymerase chain reaction; PTCL, peripheral T-cell lymphoma, not otherwise specified; TCR, T-cell receptor; TPLL, T-cell prolymphocytic leukemia; +, TCR clonal rearrangement detected.
Mean (range) for GS-1, 70.6% (6.72%−99.31%); and for GS-2, 84.6% (58.32%−98.68%).
All CD4+ or CD8+ T cells are neoplastic, and GS-2 is not applicable.
No apparent aberrancy in T-cell antigen expression detected, and GS-2 is not applicable.