▮Table 3▮.
Comparison of GS-1 and GS-2 in Cases Not Demonstrating TCR-Vβ Restriction*
Diagnosis/Case No. | T Cells in GS−1 Negative f or All Vp Tested (%) |
T Cells in GS−2 Negative for All Vp Tested (%) | Clonality by TCR PCR |
---|---|---|---|
ATLL | |||
1 | 90.76 | † | + |
2 | 61.06 | 73.4 | + |
4 | 83.05 | 86.76 | + |
5 | 89.79 | 90.16 | + |
9 | 98.6 | 99.03 | + |
13 | 78.64 | 92.79 | + |
18 | 95.26 | 97.49 | + |
20 | 52.46 | 71.65 | + |
23 | 71.81 | 82.63 | + |
CTCL | |||
25 | 81.44 | ‡ | + |
27 | 94.4 | † | ND |
LGL | |||
37 | 71.55 | † | + |
38 | 90.02 | 95.5 | ND |
41 | 70.56 | ‡ | + |
ATLL, human T-lymphotropic virus-1–associated adult T-cell leukemia/lymphoma; CTCL, cutaneous T-cell lymphoma; GS, gating strategy; LGL, T-cell large granular lymphocytic leukemia; ND, not done; PCR, polymerase chain reaction; TCR, T-cell receptor; +, clonal rearrangement detected.
Mean (range) for GS-1, 80.7% (52.46%−98.6%); and for GS-2, 87.7% (71.65%−99.03%).
All CD4+ or CD8+ T cells are tumor, and GS-2 not different from GS-1.
No aberrancy in T-cell antigen expression detected, and GS-2 is not applicable.