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. Author manuscript; available in PMC: 2020 Jul 27.
Published in final edited form as: J Med Chem. 2011 Jan 21;54(4):1003–1009. doi: 10.1021/jm101232t

Figure 1.

Figure 1.

Top1-mediated DNA cleavage induced by CPT, compound 9, and compound 11. First lane, DNA substrate alone; second lane, DNA substrate in the presence of Top1; third lane, DNA substrate in the presence of Top1 and DMSO (drug solvent). Other lanes show the results obtained with three different compounds at the indicated concentrations (100, 10, 1, and 0.1 μM).