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. Author manuscript; available in PMC: 2020 Jul 27.
Published in final edited form as: J Med Chem. 2011 Jan 21;54(4):1003–1009. doi: 10.1021/jm101232t

Figure 2.

Figure 2.

Top1-mediated DNA cleavage induced by 10 μM CPT on DNA oligonucleotides bearing the 2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPO) paramagnetic probe. Four different concentration of enzyme were tested (lane 1, without enzyme; lane 2, dilution 1:20; lane 3, dilution 1:10; lane 4, dilution 1:2).