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. Author manuscript; available in PMC: 2020 Jul 27.
Published in final edited form as: J Med Chem. 2011 Jan 21;54(4):1003–1009. doi: 10.1021/jm101232t

Scheme 1.

Scheme 1.

Synthesis Procedure for the Preparation of the 4-Amino-2,2,6,6-tetramethylpiperidin-1-oxyl Probea

a (a) NH2OH·HCl, sodium acetate, H2O; (b) LiAlH4, THF; (c) Ac2O, Et2O; (d) H2O2, Na2WO4, EDTA·2Na+, Na2CO3, H2O, RT, 2 days; (e) KOH 15% in H2O.