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. Author manuscript; available in PMC: 2021 Jan 7.
Published in final edited form as: Basic Res Cardiol. 2020 Jan 7;115(2):10. doi: 10.1007/s00395-019-0771-9

Fig. 9.

Fig. 9

Type 2 diabetes increases caspase-1 activation in human atrial tissue. a Ratios of active caspase-1 (p20) to pro-caspase-1 (p45), b mature IL-1β to pro-IL-β, and c pore-forming N-terminal (Nt) to full-length (Fl) GSDMD, in lysates of right atrial appendages from non-diabetic control patients (Ctl, n = 13) and patients with type 2 diabetes mellitus (DM, n = 15). Data show mean ± SD, relative to Ctl. *P < 0.05 vs. Ctl. d Correlation between abundance of PAR4/γ-tubulin and ratio of caspase-1/pro-caspase-1, e ratio of IL-1β/pro-IL-1β and f ratio of GDSMD-Nt/full-length GSDMD, in human right atrial appendages (n = 28). r = Pearson’s coefficient of correlation (95% confidence interval)