Table 2.
HCRU per patient during the entire follow-up by maximum LOT received.
| HCRU | All Patients (N = 1,873) |
No Chemotherapy (n = 1,035) |
LOT1 Only (n = 514) |
LOT1 & LOT2 Only (n = 209) |
LOT3+ (nN = 115) |
P-value, LOT3+ vs No Chemotherapy |
|---|---|---|---|---|---|---|
| Bladder biopsy | ||||||
| N (%) of patients | 1,751 (93.5) | 920 (88.9) | 510 (99.2) | 206 (98.6) | 115 (100.0) | < .001 |
| Mean (SD) | 2.85 (2.36) | 2.22 (1.84) | 3.41 (2.62) | 3.83 (2.72) | 4.18 (2.83) | < .001 |
| Median (IQR) | 2 (1–4) | 2 (1–3) | 3 (2–4) | 3 (2–4) | 3 (2–5) | |
| Cystoscopy | ||||||
| N (%) of patients | 1,306 (69.7) | 606 (58.6) | 426 (82.9) | 175 (83.7) | 99 (86.1) | < .001 |
| Mean (SD) | 1.61 (2.11) | 1.11 (1.71) | 2.03 (2.18) | 2.42 (2.72) | 2.77 (2.51) | < .001 |
| Median (IQR) | 1 (0–2) | 1 (0–1) | 1.50 (1–2) | 2 (1–3) | 2 (1–4) | |
| Cystectomy | ||||||
| N (%) of patients | 606 (32.4) | 248 (24.0) | 223 (43.4) | 90 (43.1) | 45 (39.1) | < .001 |
| Mean (SD) | 0.33 (0.49) | 0.25 (0.45) | 0.45 (0.52) | 0.44 (0.53) | 0.42 (0.55) | < .001 |
| Median (IQR) | 0 (0–1) | 0 (0–0) | 0 (0–1) | 0 (0–1) | 0 (0–1) | |
| Radiation | ||||||
| N (%) of patients | 612 (32.7) | 231 (22.3) | 198 (38.5%) | 110 (52.6%) | 73 (63.5%) | < .001 |
| Mean (SD) | 2.16 (3.99) | 1.20 (2.89) | 2.57 (4.15) | 4.17 (5.13) | 5.39 (5.75) | < .001 |
| Median (IQR) | 0 (0–3) | 0 (0–0) | 0 (0–4) | 2 (0–8) | 4 (0–10) | |
| Bone scan | ||||||
| N (%) of patients | 975 (52.1) | 447 (43.2) | 313 (60.9) | 134 (64.1) | 81 (70.4) | < .001 |
| Mean (SD) | 0.75 (1.06) | 0.50 (0.64) | 0.88 (1.03) | 1.13 (1.30) | 1.81 (2.25) | < .001 |
| Median (IQR) | 1 (0–1) | 0 (0–1) | 1 (0–1) | 1 (0–2) | 1 (0–2) | |
| CT scan | ||||||
| N (%) of patients | 1,799 (96.0) | 965 (93.2) | 512 (99.6) | 208 (99.5) | 114 (99.1) | .007 |
| Mean (SD) | 4.82 (4.00) | 3.10 (2.41) | 6.07 (3.81) | 7.40 (4.37) | 10.10 (5.94) | < .001 |
| Median (IQR) | 4 (2–6) | 2 (1–4) | 5 (3–8) | 6 (4–9) | 9 (6–13) | |
| MRI scan | ||||||
| N (%) of patients | 590 (31.5) | 244 (23.6) | 189 (36.8) | 94 (45.0) | 63 (54.8) | < .001 |
| Mean (SD) | 0.54 (1.11) | 0.35 (0.74) | 0.62 (1.06) | 0.91 (1.56) | 1.29 (2.12) | < .001 |
| Median (IQR) | 0 (0–1) | 0 (0–0) | 0 (0–1) | 0 (0–1) | 1 (0–2) | |
| PET-CT scan | ||||||
| N (%) of patients | 414 (22.1) | 105 (10.1) | 157 (30.5) | 88 (42.1) | 64 (55.7) | < .001 |
| Mean (SD) | 0.46 (1.22) | 0.12 (0.44) | 0.56 (1.17) | 0.94 (1.45) | 2.10 (2.91) | < .001 |
| Median (IQR) | 0 (0–0) | 0 (0–0) | 0 (0–1) | 0 (0–2) | 1 (0–4) | |
| Hospital admission | ||||||
| N (%) of patients | 1,759 (93.9) | 949 (91.7) | 497 (96.7) | 200 (95.7) | 113 (98.3) | .009 |
| Mean (SD) | 3.14 (2.43) | 2.52 (1.90) | 3.61 (2.53) | 4.12 (3.01) | 4.83 (3.12) | < .001 |
| Median (IQR) | 3 (1–4) | 2 (1–3) | 3 (2–5) | 4 (2–5) | 4 (3–6) | |
| Length of hospital stay, days† | ||||||
| Mean (SD) | 9.6 (7.0) | 10.9 (8.3) | 8.7 (4.9) | 7.6 (3.8) | 7.1 (4.0) | < .001 |
| Median (IQR) | 8.0 (5.5–11.5) | 8.4 (6.0–13.0) | 7.5 (5.5–10.4) | 6.7 (5.0–9.5) | 6.0 (4.8–8.0) | |
| Emergency department visit | ||||||
| N (%) of patients | 1,690 (90.2) | 923 (89.2) | 461 (89.7) | 195 (93.3) | 111 (96.5) | .009 |
| Mean (SD) | 3.46 (3.22) | 2.97 (2.63) | 3.72 (3.37) | 4.57 (4.49) | 4.75 (3.60) | < .001 |
| Median (IQR) | 3 (1–5) | 2 (1–4) | 3 (2–5) | 3 (2–6) | 4 (2–7) | |
| Intensive care unit visit | ||||||
| N (%) of patients | 994 (53.1) | 490 (47.3) | 311 (60.5) | 125 (59.8) | 68 (59.1) | .016 |
| Mean (SD) | 0.88 (1.19) | 0.74 (1.03) | 1.05 (1.40) | 1.00 (1.20) | 1.07 (1.32) | .004 |
| Median (IQR) | 1 (0–1) | 0 (0–1) | 1 (0–2) | 1 (0–1) | 1 (0–2) | |
| Office visit | ||||||
| N (%) of patients | 1,873 (100.0) | 1,035 (100.0) | 514 (100.0) | 209 (100.0) | 115 (100.0) | > .999 |
| Mean (SD) | 30.5 (37.4) | 13.8 (24.5) | 41.4 (36.7) | 57.2 (36.3) | 84.7 (40.8) | < .001 |
| Median (IQR) | 18 (6–42) | 7 (3–16) | 32 (18–52) | 47 (34–69) | 75 (55–107) |
Abbreviations. CT, computed tomography; HCRU, healthcare resource use; IQR, interquartile range; LOT, line of therapy; MRI, magnetic resonance imaging; PET-CT, positron emission tomography-computed tomography; SD, standard deviation.
†
Length of stay defined as total number of days hospitalized per patient across all hospital admissions.