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. Author manuscript; available in PMC: 2020 Jul 27.
Published in final edited form as: Pharm Res. 2019 Nov 26;36(12):185. doi: 10.1007/s11095-019-2721-5

Figure 2 -. Variation of NP cytosolic transfer for tumor lesion of VERY LOW vascular heterogeneity,

Figure 2 -

showing spatial distribution of PLGA NPs and cisplatin (CDDP) in the three compartments of the model. The NP cytosolic transfer coefficient was varied from low (=0), medium (=5), and high (=50) values. Images are from the first output interval immediately after bolus injection of CDDP-loaded NPs (Panels A, C, E) and the second output interval after the drug has taken effect (Panels B, D, F). Drug concentration is shown for extracellular (μM), cytosolic (Fmol × hr), and DNA-bound (Fmol × hr) compartments. Colors are as in Figure 1. Bar = 200 μm.