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. Author manuscript; available in PMC: 2020 Jul 27.
Published in final edited form as: Pharm Res. 2019 Nov 26;36(12):185. doi: 10.1007/s11095-019-2721-5

Figure 4 -. Variation of NP aggregation for tumor lesion of VERY LOW vascular heterogeneity,

Figure 4 -

showing spatial distribution of PLGA NPs and cisplatin (CDDP) in the three compartments of the model. NP aggregation was varied from low (5×5 blocks), medium (10×10 blocks), and high (15×15 blocks). Images are from the first output interval (immediately after bolus injection of CDDP-loaded NPs (Panels A, C, E) and the second output interval (after the drug has taken effect (Panels B, D, F). Drug concentration is shown for extracellular (μM), cytosolic (Fmol × hr), and DNA-bound (Fmol × hr) compartments. Colors are as in Figure 1. Bar = 200 μm.