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. Author manuscript; available in PMC: 2020 Jul 27.
Published in final edited form as: Pharm Res. 2019 Nov 26;36(12):185. doi: 10.1007/s11095-019-2721-5

Figure 5 -. Extracellular and cytosolic nanoparticle area-under-the-curve (AUC) as a function of vasculature-induced tumor tissue heterogeneity.

Figure 5 -

Graphs represent the magnitude of the AUC calculated within the tumor boundary at every output interval during treatment with cisplatin-loaded NPs. (A) Extracellular and (B) Cytosolic NP AUC due to variation in NP cytosolic transfer rate (non-dimensional units); (C) Extracellular and (D) NP AUC due to variation in NP aggregation (non-dimensional units).