. Author manuscript; available in PMC: 2020 Jul 27.

Published in final edited form as: Pharm Res. 2019 Nov 26;36(12):185. doi: 10.1007/s11095-019-2721-5

Table III.

Nanoparticle kinetic parameters (based on (33, 43) and associated references).

Parameter	Description	Value
Vc	Cell Volume (fL/cell)	520
F	Interstitial Fraction	0.48
D_E	NP Diffusivity (μm²/min)	3E-3
k_EC	Cytosolic transfer coefficient	Varied: 0,5,10 and 50
k_CE	Cytosolic efflux coefficient	1.5E-3 (estimated)
k_D	Lysosomal loss	2E-3 (estimated)