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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Lung Cancer. 2020 May 25;146:189–196. doi: 10.1016/j.lungcan.2020.05.017

Figure 2. Gene expression changes in COPD and lung cancer.

Figure 2.

The expression levels of (A) CCNA1, (B) SNCA, and (C) ZNF549 in normal lung tissues (NLT) obtained from cancer-free never smokers (NLT-NS) and smokers (NLT-S), tumor-normal pairs from lung cancer patients, and NSCLC cell lines were quantified using gene-specific expression assays. The distant normal lung tissue (DNLT) and tumor pairs were all from smoker LUAD cases with or without COPD. Thus, they were separated into the following 4-groups: DNLT without COPD (DNLT-COPD) or with COPD (DNLT+COPD) and tumors without COPD (Tumor-COPD) or with COPD (Tumor+COPD). Expression is measured relative to the level in NLT-NS and the significant changes from NLT-NS (✭), NLT-S (◆), DNLT-COPD (Δ), DNLT+COPD (☐), or Tumor-COPD (■) are shown. D) RNA-seq data for the expression of CCNA1, SNCA, and ZNF549 in normal lung tissues and LUAD samples from TCGA database was used to independently validate the repression of these genes.