Table 3.
Characteristics of the Patients with Neurological Dysfunction and ABR Pathology.
| Case | Group | Maximum sTB level (mg/dl) | Duration of exposure to sTB levels>20 mg/dl (hours) | Treatment | Neurologic assessment | Denver II Test | Cranial MRI | OAE | ABR |
|---|---|---|---|---|---|---|---|---|---|
| 1 | m | 37.2 | 24 | PT+ET (Twice) | Moderate to severe psychomotor retardation, limitation of vertical eye movements, hipotoni. | Abnormal (Chronological age: 18 months. Developmental age: personal- social, language and gross motor 8-9 months, fme motor 11-12 months) | Bilateral symmetrical increased intensity in T2 section of globus pallidus and subthalamic nuclei | Bilateral passed | No waveforms were recorded, cochlear microphonics were obtained (auditory neuropathy spectrum disorder) |
| 2 | m | 51 | 20.5 | PT+ET (Twice) | Severe motor and moderate psychosocial retardation, spasticity, choreoatetoid cerebral palsy | Abnormal (Chronological age: 20 months. Developmental age: personal- social, language and motor development 2-3 months) | Cerebral atrophy | Bilateral failed | Wave V at 90 dBnHL (maximum intensity) level was not observed in the left ear. Wave V was normal up to 60dBnHL in the right ear, and lower levels could not be recorded (bilateral cochlear hearing loss). |
| 3 | m | 29,7 | 16 | PT+ET (Once) | Mild psychosocial motor retardation | Abnormal (Chronological age: 21 months. Developmental age: language 12-13 months, personal-social and gross motor 14-15 months, fine motor 18-19 months) | Normal | Bilateral passed | Bilateral normal recording was obtained. |
| 4 | IV | 44,6 | 29.5 | PT+ET (Thrice) | Mild psychosocial motor retardation | Abnormal (Chronological age: 20 months. Developmental age: language 11-12 months, personal-social and gross motor 14-15 months, fine motor 18-19 months) | Normal | Bilateral failed | Wave V was normal up to 70 dBnHL in the right ear, and lower levels could not be recorded. Waves were normal up to 60 dBnHL in the left ear, and lower levels could not be recorded (bilateral cochlear hearing loss). |
| 5 | IV | 33,9 | 16 | PT+ET (Once) | Mild psychosocial motor retardation, minimal spasticity | Abnormal (Chronological age: 18 months. Developmental age: language 7-8 months, personal-social and gross motor 11-12 months, fme motor 18 months) | Bilateral symmetrical increased intensity in T2 section of bilateral globus pallidus | Bilateral failed (nasal congestion and adenoid vegetation!) | No waveforms were recorded, cochlear microphonics were obtained (auditory neuropathy spectrum disorder) |
sTB; serum total bilirubin, PT; phototherapy, ET; exchange transfusion, MRI; magnetic resonance imaging, OAE; otoacustic emission; ABR; auditory brainstem response