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. Author manuscript; available in PMC: 2020 Jul 27.
Published in final edited form as: Mol Cell Endocrinol. 2019 Jan 17;487:59–65. doi: 10.1016/j.mce.2019.01.015

Figure 1: Scheme for antifibrotic signaling of relaxin-2.

Figure 1:

Relaxin-2 activates RXFP1, which stimulates NO/cGMP/PKG1 signaling. Activation of the relaxin-RXFP1 axis subsequently leads to the inhibition of pERK1/2 and pSmad2/3, which ultimately suppresses TGFβ-induced fibrosis.

PKG1 – cGMP-dependent protein kinase 1, sGC – soluble guanylyl cyclase, cGMP – cyclic guanosine monophosphate, ERK – extracellular-signal regulated kinase, GMP – guanosine monophosphate, NOS – nitric oxide synthase, PDE5 – phosphodiesterase 5, RXFP1 – relaxin family peptide receptor 1, Smad – small mothers against decapentaplegic protein, TGFβ – transforming growth factor-β