Table 2.
Univariate logistic regression model and multivariable backwards logistic regression model for associations of variables with RLN positivity
| Variable | RLN metastasis (n = 742) | No RLN metastasis (n = 2587) | Univariate analysis | Multivariable analysis | ||
|---|---|---|---|---|---|---|
| Odds ratio (95% CI) | p value | Odds ratio (95% CI) | p value | |||
| Age (year) | ||||||
| ≥ 50 | 569 (77%) | 2171 (84%) | Reference | Reference group | ||
| < 50 | 173 (23%) | 407 (16%) | 1.62 (1.33, 1.98) | < 0.001 | 1.61 (1.27, 2.05) | < 0.001 |
| Tumor size (cm) | ||||||
| < 1 | 71 (10%) | 810 (32%) | Reference | Reference group | ||
| 1–2 | 301 (41%) | 1102 (43%) | 3.12 (2.37, 4.10) | < 0.001 | 2.61 (1.92, 3.54) | < 0.001 |
| 2–5 | 363 (49%) | 647 (25%) | 6.40 (4.86, 8.42) | < 0.001 | 4.16 (3.03, 5.70) | < 0.001 |
| Grade | ||||||
| 1 | 105 (14%) | 713 (28%) | Reference | Reference group | ||
| 2 | 396 (54%) | 1141 (45%) | 2.36 (1.86, 2.98) | < 0.001 | 1.66 (1.27, 2.16) | < 0.001 |
| 3 | 231 (32%) | 705 (28%) | 2.23 (1.73, 2.87) | < 0.001 | 0.99 (0.73, 1.34) | 0.928 |
| LVI | ||||||
| Negative | 469 (65%) | 2312 (92%) | Reference | Reference group | ||
| Positive | 254 (35%) | 209 (8%) | 5.99 (4.87, 7.38) | < 0.001 | 4.73 (3.73, 5.99) | < 0.001 |
| Systemic metastasis | ||||||
| No | 616 (84%) | 2431 (94%) | Reference | Reference group | ||
| Yes | 119 (16%) | 143 (6%) | 3.28 (2.54, 4.25) | < 0.001 | 2.34 (1.71, 3.20) | < 0.001 |
| ER | ||||||
| Negative | 124 (17%) | 515 (20%) | Reference | |||
| Positive | 613 (83%) | 2051 (80%) | 1.24 (1.00, 1.54) | 0.050 | ||
| PR | ||||||
| Negative | 174 (24%) | 683 (27%) | Reference | |||
| Positive | 565 (76%) | 1891 (73%) | 1.17 (0.97, 1.42) | 0.102 | ||
| HER2/neu | ||||||
| Negative | 512 (77%) | 1940 (82%) | Reference | |||
| Positive | 152 (23%) | 427 (18%) | 1.35 (1.09, 1.66) | 0.005 | ||
ER estrogen receptor; LVI lymphovascular invasion; PR progesterone receptor; RLN regional lymph node